Case report: systemic tuberculosis caused by Mycobacterium bovis in a cat- Abstract



Mycobacterium bovis was isolated from the lungs, bronchial and gastrointestinal lymph nodes, kidney and liver of a 5-year-old stray male cat. The isolate was confirmed as M. bovis using the Genotype MTBC assay (Hain Lifescience, Germany), which allows differentiation of species within the Mycobacterium tuberculosis complex. The Systemic tuberculosis was diagnosed via postmortem examination of the cat. Pathological changes included multifocal to coalescing granulomatous inflammation in the lungs, liver, lymph nodes and kidneys. Infection by immunosuppressive viral pathogens including feline herpes virus-1, feline immunodeficiency virus and feline parvovirus virus were ruled out by polymerase chain reaction assay (PCR). The isolated M. bovis was susceptible to isoniazid, ethambutol, rifampicin or streptomycin. Unlike previous cases of feline tuberculosis in Turkey, this case report details the first case of feline tuberculosis in Turkey for which the causative agent (M. bovis) was confirmed with bacteria isolation, morphological evaluation, molecular characterization and antibiotic sensitivity.



  1. Multifocal granulomatous pneumonia (arrowhead) and diffuse lymphadenitis (arrow) of tracheobronchial lymph nodes. 2. Diffuse, severe lymphadenitis in mesenteric lymph nodes (arrow). 3. Multifocal granulomatous nephritis. 4. Gastric worms on the mucosal surface (arrows). 5.6.7. Granulomatous pneumonia (5) with necrosis (N), lymphadenitis (6) and necrosis and nephritis (7) with granulomas (arrows), HE. 8. Acid-fast microorganisms in the cytoplasm of epithelioid macrophages (arrows), ZN